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Arsitri (Arsenic Trioxide ):



1mg/ml (10ml Vial)
MRP Our Price
Rs. 351.00 Rs. 294.84
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Brand Name - Arsitri

Generic Name - Arsenic Trioxide 
What is it used for?
Treatment of acute promyelocytic(Myeloid) leukaemia (APL) in people who have already had other types of treatment, including a retinoid and chemotherapy, which have not worked well or no longer work.
How does it work?
It is used for the treatment of acute promyelocytic leukaemia (APL).
The bone marrow produces cells called stem cells. These normally develop into the different types of blood cells (white blood cells, red blood cells and platelets) and when these are mature they leave the bone marrow and enter the bloodstream.
In leukaemia the bone marrow produces too many immature white blood cells. These abnormal cells take up space in the bone marrow and result in less room for production of normal healthy blood cells. Acute promyelocytic leukaemia is a specific type of acute myeloid leukaemia in which the abnormal white blood cells cause problems with abnormal bleeding and bruising to occur.
It is not fully understood how arsenic trioxide works in treatment of promyelocytic leukaemia. However, it is known to damage cancer cells by causing the DNA structure to be changed and preventing the growth and multiplication of cancer cells.
Unfortunately, arsenic trioxide can also affect normal, healthy cells, particularly those that multiply quickly, such as blood cells and hair cells. The most important side effect is on the bone marrow where blood cells are made. Arsenic trioxide can temporarily decrease the production of healthy blood cells, leaving people susceptible to infection. Regular blood tests are therefore needed to monitor the levels of blood cells.
In most chemotherapy regimens, doses are administered in courses at various intervals to allow normal cells to recover from the adverse effects of the anticancer medicines between doses. However, during this period, cancer cells will also recover and start to replicate again. Successful treatment depends on the administration of the next course of therapy before the cancer cells reach their previous numbers and the net effect is to decrease the amount of cancer with each successive course.
How is this treatment given?
It is given via a drip into a vein (intravenously) over one to two hours by a doctor or nurse. It may be given over a longer period of time if you get side effects such as flushing or dizziness.
The infusion is given daily until the leukaemia is in remission, for a maximum of 50 days. If no change in your condition is seen, then treatment will be discontinued. If this treatment is well tolerated and there has been an improvement in your condition, your doctor will start you on a consolidation treatment schedule (second treatment cycle) three to four weeks after the first course of treatment is completed.
The second treatment cycle involves having an infusion every day for five days, followed by a two day break. This is repeated for a total of five weeks.
This medicine can affect your heartbeat. For this reason your heart will need to be monitored with an ECG before treatment is started and regularly throughout your treatment. If you have any existing heart problems your heart may need to be continuously monitored with an ECG during your treatment.
Tell your doctor straight away if you notice any of the following side effects while you are having treatment with this medicine: shortness of breath, coughing, chest pain, fever, sudden weight gain, water retention or swelling, fainting or palpitations (awareness of your heartbeat).
During treatment with this medicine you will need to have regular blood tests to monitor your blood cells, your kidney and liver function and the levels of electrolytes (salts such as potassium and magnesium) and sugar in your blood.
This medicine can affect the number of healthy blood cells in your blood. A low white blood cell count can increase your susceptibility to infections; a low red blood cell count causes anaemia and a low platelet count can cause problems with blood clotting. Tell your doctor immediately if you experience any of the following symptoms during your treatment, as they may indicate problems with your blood cells: unexplained bruising or bleeding, purple spots, black or tarry stools, sore mouth or throat, mouth ulcers, high temperature (fever) or other signs of infection, or suddenly feeling tired, breathless, or generally unwell.
This medicine may be harmful to an unborn baby, and for this reason you should use effective contraception to avoid getting pregnant or fathering a child during treatment. You should continue to use contraception to prevent pregnancy for at least a few months after treatment with this medicine is stopped, but discuss this with your doctor. Women should consult their doctor immediately if they get pregnant during treatment.
Your ability to get pregnant or father a child may be affected by this medicine. It is important to discuss fertility with your doctor before starting treatment.
The safety and effectiveness of this medicine in children under five years old have not been studied.
Use with caution in
Elderly people.
Decreased liver function.
Decreased kidney function.
People with heart disease, such as heart failure, irregular heartbeats or a previous heart attack.
People with a personal or family history of a type of abnormal heart beat seen on a heart monitoring trace (ECG) as a 'prolonged QT interval'.
People taking other medicines that can increase the risk of a ‘prolonged QT interval’.
People who have previously had treatment with anthracycline chemotherapy medicines such as doxorubicin (these can affect the heart).
People with low levels of potassium or magnesium in their blood.
Not to be used in
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
The safety of this medicine for use in pregnancy has not been studied in humans. It should not be used in pregnancy, unless considered essential by your doctor due to life-threatening disease, because it is likely to be harmful to a developing baby.
Women who could get pregnant should use effective contraception to prevent pregnancy, and men should use effective contraception to prevent fathering a child, both during treatment, and for at least a few months after treatment is finished. Seek further medical advice from your doctor.
This medicine passes into breast milk and will be harmful to a nursing infant. Mothers who need treatment with this medicine should not breastfeed. Seek medical advice from your doctor.
Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
Increased blood sugar level (hyperglycaemia).
Decreased level of potassium in the blood (hypokalaemia).
Shortness of breath or painful breathing.
Pins and needles sensations.
Pain in the bones or joints.
Elevated liver enzyme levels.
Decrease in the number of healthy white blood cells or platelets in the blood (neutropenia or thrombocytopenia) – see warning section above.
Abnormal heart rhythm, seen as a ‘prolonged QT interval’ on an ECG.
Chest pain.
Increased heart rate (tachycardia).
Heart disorders, such as leaking of fluid into the sac surrounding the heart (pericardial effusion) or heart failure.
Build-up of fluid between the layers of tissue that line the lungs and chest cavity (pleural effusion).
Increased level of white blood cells in the blood (leucocytosis).
Increased levels of magnesium or sodium in the blood (hypermagnesaemia or hypernatraemia).
Low levels of magnesium in blood (hypomagnesaemia).
Low levels of oxygen in the tissues (hypoxia).
Skin reactions such as rash, redness and itching.
Pain in the muscles (myalgia).
Infections – including pneumonia, chickenpox or shingles and blood infections (sepsis).
Excessive fluid retention in the body tissues, resulting in swelling (oedema).
Blurred vision.
Low blood pressure.
Feeling sick, vomiting or abdominal pain.
Kidney failure.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
Disclaimer: The information provided above is general. It does not include all possible uses, actions, precautions, side effects, or interactions. It is not intended as medical advice, and should not be relied upon as a substitute for your doctor’s advice. Please consult your doctor before taking any action towards your medical condition.

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