Generic Name - Gemcitabine
Why would this drug be used?
Gemcitabine is used to treat pancreatic cancer, breast cancer, ovarian cancer, bladder cancer and lung cancer small cell, and may be used for other cancers as well.
How does this drug work?
Gemcitabine is a member of a general group of chemotherapy drugs known as anti-metabolites. It prevents cells from making DNA and RNA, which stops cell growth and causes the cells to die.
Before taking this medicine Tell your doctor…
If you are allergic to anything, including medicines, dyes, additives, or foods.
If you have any medical conditions such as kidney disease, liver disease (including hepatitis), heart disease, congestive heart failure, diabetes, gout, or infections. These conditions may require that your medicine dose, regimen, or timing be changed.
If you are pregnant, trying to get pregnant, or if there is any chance of pregnancy. This drug may cause birth defects if either the male or female is taking it at the time of conception or during pregnancy. Check with your doctor about what kinds of birth control can be used with this medicine.
If you are breast-feeding. It is not known whether this drug passes into breast milk. If it does, it could harm the baby.
If you think you might want to have children in the future. Some drugs can cause sterility. Talk with your doctor about the possible risk with this drug and the options that may preserve your ability to have children.
About any other prescription or over-the-counter medicines you are taking, including vitamins and herbs. In fact, keeping a written list of each of these medicines (including the doses of each and when you take them) with you in case of emergency may help prevent complications if you get sick.
How is this drug taken or given?
Gemcitabine is given as an injection in a vein over a period of 30 minutes. Pancreatic cancer patients are given gemcitabine once a week for up to 7 weeks to start, then a week without treatment. After that, the dose is once a week for 3 weeks followed by a week off. When given for breast or ovarian cancer, it's usually once a week for 2 weeks, then 1 week off. For lung cancer or other cancer patients, it usually is given weekly for 3 weeks with 1 week off. The dose depends on your size, your blood counts, how well you did on the last cycle of treatment, and the cancer being treated.
Your doctor will likely test your blood throughout your treatment, looking for possible effects of the drug on blood counts or on your liver or kidneys. Based on the test results, you may be given medicines to help treat any effects. Your doctor may also need to reduce or delay your next dose of this drug, or even stop it altogether. Be sure to keep all your appointments for lab tests and doctor visits.
This drug can lower your white blood cell count, especially in the weeks after the drug is given. This can increase your chance of getting an infection. Be sure to let your doctor or nurse know right away if you have any signs of infection, such as fever (100.5° or higher), chills, pain when passing urine, a new cough, or bringing up sputum.
This drug may lower your platelet count in the weeks after it is given, which can increase your risk of bleeding. Speak with your doctor before taking any drugs or supplements that might affect your body's ability to stop bleeding, such as aspirin or aspirin-containing medicines, warfarin (Coumadin), or vitamin E. Tell your doctor right away if you have unusual bruising, or bleeding such as nosebleeds, bleeding gums when you brush your teeth, or black, tarry stools.
This drug may lower your red blood cell count. If this occurs, it is usually a few weeks after starting treatment. A low red blood cell count (known as anemia) can cause shortness of breath, or make you to feel weak or tired all the time. Your doctor may give you medicines to help prevent or treat this condition, or you may need to get blood transfusions.
Do not get any immunizations (vaccines), either during or after treatment with this drug, without your doctor's OK. Gemcitabine may affect your immune system. This could make vaccinations ineffective, or could even lead to serious infections if you get a live virus vaccine during or soon after treatment. Try to avoid contact with people who have recently received a live virus vaccine, such as the oral polio vaccine or smallpox vaccine. Check with your doctor about this.
Avoid pregnancy during and for at least a few months after treatment, since exposure to this drug may harm the fetus. Talk with your doctor about this.
Possible side effects
You will probably not have most of the following side effects, but if you have any talk to your doctor or nurse. They can help you understand the side effects and cope with them.
low white blood cell count with increased risk of infection*
low platelet count with increased risk of bleeding*
low red blood cell count (anemia) with symptoms like tiredness, weakness, or shortness of breath*
loss of appetite
swelling of the arms and legs or other parts of the body
abnormal blood tests which suggest that the drug is affecting the liver or kidneys (Your doctor will discuss the importance of this finding, if any.)
sores in mouth or on lips
flu-like symptoms (headache, muscle aches, fever)
trouble breathing or shortness of breath
swelling of hands, ankles, or face
hair loss or thinning, which may include face and body hair
sleepiness or drowsiness (sedation)
numbness or tingling
death due to kidney failure, liver failure, lung damage, infection, or other causes
There are some other side effects not listed above that can also occur in some patients. Tell your doctor or nurse if you develop these or any other problems.